Accessing Pyrido[1,2-α]pyrimidines through Click Chemistry

Author

Omar Afifi, College of the Holy Cross

Date of Creation

5-24-2024

Document Type

Campus Access Only

Department

Chemistry

First Advisor

André K. Isaacs

Abstract

Nitrogen heterocycles are present in 59 percent of FDA approved small-molecule drugs. Efforts were made to synthesize N-Tosyl-4-imino-4H-pyrido[1,2-α]pyrimidine, a fused N-heterocycle, in two steps. This class of compounds, pyrido[1,2-α]pyrimidines, display useful properties such as antiviral and antibacterial activities, which suggests therapeutic potential. Our synthetic approach utilized click chemistry, specifically the Copper-Catalyzed Azide-Alkyne Cycloaddition (CuAAC), by combining a terminal alkyne with tosyl azide to form a more reactive class of species called ketenimines. We hope to explore the synthetic utility of our methodology by testing different substrates upon successful optimization of reaction conditions.

Comments

Reader: Joshua R. Farrell

Recommended Citation

Afifi, Omar, "Accessing Pyrido[1,2-α]pyrimidines through Click Chemistry" (2024). College Honors Program. 101.
https://crossworks.holycross.edu/honors/101